Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S_N1 and S_N2 Processes

摘要

Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S_N1 and S_N2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations